Symbol
Name
ID

Nkx2-1
NK2 homeobox 1
MGI:108067

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Frequent falls	Chorea	Dysarthria	Anxiety	Dementia	Abnormality of movement	Gait disturbance	Motor delay
Disease(s) Associated with NKX2-1
choreatic disease

Mouse Phenotypes

nervous system phenotype

abnormal adenohypophysis development

abnormal Rathke's pouch apoptosis

abnormal Rathke's pouch development

absent infundibular recess of third ventricle

absent pituitary infundibular stalk

abnormal pituitary gland development

absent pituitary gland

abnormal forebrain morphology

abnormal diencephalon morphology

abnormal hypothalamus morphology

abnormal ventromedial hypothalamic nucleus morphology

decreased ventromedial hypothalamic nucleus size

Availability

Mouse Genotype

Nkx2-1^tm1Shk/Nkx2-1^tm1Shk

Nkx2-1^tm2Rdl/Nkx2-1^tm2Rdl

Nkx2-1^tm2Shk/Nkx2-1^tm2Shk
Tg(Syn1-cre)671Jxm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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